Yes, the TPA3118 PBTL Mono Digital Amplifier is fully compatible with Arduino, Raspberry Pi, ESP32, and most microcontroller platforms. It accepts a wide operating voltage (8–24V) and delivers powerful 60W mono output, making it suitable for high-volume speakers, subwoofers, and performance-driven audio projects. You can feed audio input from DAC modules, PWM-to-audio converters, Bluetooth modules, or standard audio sources. Its high-efficiency Class-D design, low heat generation, and stable performance make it ideal for DIY audio systems, robotics, home automation, custom speakers, and embedded sound applications. It works well for both beginners and advanced audio developers building high-power amplifier setups.